Description

2-(Trifluoromethoxy)-Benzenepropanoic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethoxy group imparts desirable metabolic stability and lipophilicity. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this unique pharmacophore into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy moiety enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the synthesis of specialized monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductor materials.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination chemistry in academic and industrial R&D labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	2-(Trifluoromethoxy)-Benzenepropanoic Acid
CAS No.	914636-53-6
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	3-[2-(Trifluoromethoxy)phenyl]propanoic Acid; 2-(Trifluoromethoxy)hydrocinnamic Acid; Benzenepropanoic acid, 2-(trifluoromethoxy)-; α,α,α-Trifluoro-o-tolyloxyhydrocinnamic Acid; 2-Trifluoromethoxybenzenepropionic Acid; (2-Trifluoromethoxyphenyl)propionic Acid; 3-(2-(Trifluoromethoxy)phenyl)propionic Acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)-Benzenepropanoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.