Description

The Hoveyda-Snapper Desymmetrization Catalyst is a highly specialized, chiral ruthenium-based complex designed for asymmetric synthesis. This catalyst is pivotal for achieving high enantioselectivity and yield in the desymmetrization of meso compounds and related prochiral substrates, a critical transformation in modern pharmaceutical and fine chemical manufacturing. It is an essential tool for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient routes to single-enantiomer intermediates.

Application

• Asymmetric Organic Synthesis: Key catalyst for enantioselective ring-opening cross-metathesis (ROCM) and desymmetrization reactions.
• Pharmaceutical Intermediates: Production of chiral building blocks for active pharmaceutical ingredients (APIs), including antiviral and anticancer agents.
• Natural Product Synthesis: Enables the efficient, stereocontrolled construction of complex molecular architectures found in natural products.
• Agrochemical Development: Synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Used in the production of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Methodology Development: A valuable reagent in academic and industrial research for developing new catalytic asymmetric transformations.

Basic Information

Product Name	Hoveyda-Snapper Desymmetrization Catalyst
CAS No.	913831-29-5
Molecular Formula	C31H46Cl2N2ORu
Molecular Weight	626.68 g/mol
Synonyms	Hoveyda-Snapper Catalyst; Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-isopropoxybenzylidene)ruthenium(II); Grubbs-Hoveyda 2nd Generation Catalyst (modified); Zhan Catalyst 1B; Ru-indenylidene complex; Chiral ruthenium alkylidene catalyst; Desymmetrization catalyst 913831-29-5
EINECS	Contact for details

Quality Control

Every batch of our Hoveyda-Snapper Desymmetrization Catalyst is manufactured and tested under strict quality management protocols to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and catalytic activity. Our quality systems support development under cGMP guidelines for pharmaceutical applications, ensuring traceability and reliability for critical process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent decomposition. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in dichloromethane, toluene, THF
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.