Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 3-Methyl-7-Oxo-3-(1H-1,2,3-Triazol-1-Ylmethyl)-, 4-Oxide, (2S,3S,5R)- is a high-purity, non-natural β-lactam derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel antibacterial agents, particularly within the cephalosporin and penem classes. It is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on creating next-generation antibiotics to combat drug-resistant bacteria.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel β-lactam antibiotics, including advanced cephalosporins.
• Active Pharmaceutical Ingredient (API) Research: Used as a precursor or a core scaffold in the discovery and development of new antibacterial drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of new antibiotic candidates.
• Biochemical Research: Used in studies investigating bacterial resistance mechanisms and the inhibition of penicillin-binding proteins (PBPs).
• Fine Chemical Synthesis: A specialized intermediate for custom synthesis and contract manufacturing of complex, high-value molecules.

Basic Information

Item	Details
Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 3-Methyl-7-Oxo-3-(1H-1,2,3-Triazol-1-Ylmethyl)-, 4-Oxide, (2S,3S,5R)-
CAS No.	904671-24-5
Molecular Formula	C10H12N4O4S
Molecular Weight	284.29 g/mol
Synonyms	(2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide; 7-Oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid, 3-Methyl-, 4-Oxide, (2S-cis)-; Triazolylmethyl penem sulfone derivative; β-Lactam sulfone intermediate; Penem sulfone analog.
EINECS	Contact for details

Quality Control

Our 4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 3-Methyl-7-Oxo-3-(1H-1,2,3-Triazol-1-Ylmethyl)-, 4-Oxide, (2S,3S,5R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. Certificates of Analysis (COA) detailing all specifications and results are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,3S,5R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.