Description

Zidebactam is a novel, non-β-lactam β-lactamase inhibitor that plays a critical role in combating antibiotic-resistant bacterial infections. This compound is specifically designed to restore the efficacy of β-lactam antibiotics against multidrug-resistant Gram-negative pathogens, including carbapenem-resistant strains. It is an essential research chemical and active pharmaceutical ingredient (API) for pharmaceutical developers, clinical research organizations, and manufacturers focused on next-generation antibacterial therapies.

Application

• Pharmaceutical API Development: As a key component in the formulation of new combination antibacterial drugs, particularly with cefepime (WCK 5222).
• Antimicrobial Resistance (AMR) Research: For in-vitro and in-vivo studies to evaluate efficacy against β-lactamase-producing bacteria like Pseudomonas aeruginosa and Acinetobacter baumannii.
• Clinical Trial Material (CTM): Sourced for the production of batches used in Phase I-IV clinical trials for novel antibiotic combinations.
• Mechanistic Biochemical Studies: Used in research to understand the inhibition mechanisms of serine β-lactamases and penicillin-binding proteins (PBPs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in drug manufacturing.

Basic Information

Product Name	Zidebactam
CAS No.	1436861-97-0
Molecular Formula	C12H14N4O5S
Molecular Weight	326.33 g/mol
Synonyms	(2S,5R)-7-Oxo-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; Zidebactam sodium; WCK 5107; (2S,5R)-N-Hydroxy-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; ZID; Diazabicyclooctane β-lactamase inhibitor
EINECS	Contact for details

Quality Control

Our Zidebactam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Specifications align with ICH guidelines, and a detailed Certificate of Analysis (COA) providing results for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.