Description

(2S,5R)-2-Carbamoyl-3-Methyl-7-Oxo-1,6-Diazabicyclo[3.2.1]Oct-3-En-6-Ylhydrogensulfate CAS NO 1467829-71-5 is a high-purity, advanced pharmaceutical intermediate with a complex diazabicyclooctane core structure. This compound is a critical building block in the synthesis of next-generation β-lactamase inhibitors, which are essential for combating antibiotic-resistant bacterial infections. It is primarily required by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel antibacterial agents.

Application

• Key Intermediate for β-Lactamase Inhibitors: Serves as a crucial precursor in the synthesis of novel, potent inhibitors like avibactam and relebactam analogs.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs to develop new antibacterial drug candidates targeting multidrug-resistant pathogens.
• Combinatorial Chemistry: Employed in the creation of focused libraries for structure-activity relationship (SAR) studies in antibiotic research.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of commercial-scale synthetic routes for advanced antibiotic formulations.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Academic Research: Used in university and institutional labs studying enzyme inhibition mechanisms and novel antibiotic design.

Basic Information

Item	Details
Product Name	(2S,5R)-2-Carbamoyl-3-Methyl-7-Oxo-1,6-Diazabicyclo[3.2.1]Oct-3-En-6-Ylhydrogensulfate
CAS No.	1467829-71-5
Molecular Formula	C9H13N3O6S
Molecular Weight	291.28 g/mol
Synonyms	(2S,5R)-2-Carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl hydrogen sulfate; Avibactam Intermediate; NXL-104 Intermediate; AVI Intermediate; (2S,5R)-2-Carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulphate; Diazabicyclooctane sulfate ester; 1,6-Diazabicyclo[3.2.1]oct-3-ene-2-carboxamide, 6-(hydrogen sulfate), 3-methyl-, (2S,5R)-
EINECS	Contact for details

Quality Control

Our (2S,5R)-2-Carbamoyl-3-Methyl-7-Oxo-1,6-Diazabicyclo[3.2.1]Oct-3-En-6-Ylhydrogensulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,5R)-isomer
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.