Description

Zosyn CAS NO 157044-21-8 is a broad-spectrum, β-lactam/β-lactamase inhibitor combination antibiotic formulation. This injectable pharmaceutical product is critical for combating serious, multi-drug resistant bacterial infections in hospital settings. It is primarily utilized by healthcare professionals for the treatment of complicated intra-abdominal infections, skin and skin structure infections, and hospital-acquired pneumonia.

Application

The primary application of Zosyn is in clinical medicine for the treatment of severe infections. Its key uses include:

• Treatment of Complicated Intra-abdominal Infections (e.g., peritonitis, appendicitis with rupture).
• Management of Complicated Skin and Skin Structure Infections, including diabetic foot infections.
• Therapy for Nosocomial (Hospital-Acquired) Pneumonia, including ventilator-associated pneumonia.
• Empiric Therapy for Febrile Neutropenia in immunocompromised patients.
• Surgical Prophylaxis in specific high-risk procedures.
• As a key agent in antimicrobial stewardship programs for targeted use against resistant organisms.

Basic Information

Product Name	Zosyn
CAS No.	157044-21-8
Molecular Formula	C23H27N5O7S (Piperacillin) + C8H11NO5S (Tazobactam)
Molecular Weight	517.56 g/mol (Piperacillin) + 300.30 g/mol (Tazobactam)
Synonyms	Piperacillin Sodium and Tazobactam Sodium; Piperacillin/Tazobactam; Tazocin; Piptaz; Zosyn (brand name); Piperacillin-Tazobactam Combination; (2S,5R,6R)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
EINECS	Contact for details

Quality Control

Our Zosyn active pharmaceutical ingredient (API) is manufactured under strict cGMP (Current Good Manufacturing Practice) guidelines. Quality is assured through rigorous testing against USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Excursions are permitted to 2-8°C (36-46°F). For long-term stability, store under an inert atmosphere such as nitrogen.

Specification

Item	Specification
Description	White to off-white powder or crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (Piperacillin & Tazobactam)
Water Content (KF)	NMT 2.0%
pH (1% solution)	5.5 - 7.5
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	<0.05 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.