Description

N,N,n-Tributylbutan-1-Aminium [({(2S,5R)-7-Oxo-2-[(Piperidin-4-Ylamino)Carbonyl]-1,6-Diazabicyclo[3.2.1]Oct-6-Yl}Oxy)Sulfonyl]Oxidanide is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture. This compound is critical for research and development in the synthesis of novel β-lactamase inhibitors, offering a key building block for next-generation antibacterial agents. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on antimicrobial resistance and advanced synthetic chemistry.

Application

• Key Intermediate in API Synthesis: Serves as a crucial precursor in the multi-step synthesis of new-generation β-lactamase inhibitor active pharmaceutical ingredients (APIs).
• Pharmaceutical R&D: Used in medicinal chemistry programs for the design, optimization, and structure-activity relationship (SAR) studies of novel antibacterial compounds.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential drug candidates in preclinical and clinical development stages.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control, method development, and regulatory submissions.
• Academic Research: Utilized in university and institutional research projects exploring new mechanisms of action against drug-resistant bacteria.
• Fine Chemical Manufacturing: Integrated into the production of specialized, non-commercial compounds for biological screening and testing.

Basic Information

Product Name	N,N,n-Tributylbutan-1-Aminium [({(2S,5R)-7-Oxo-2-[(Piperidin-4-Ylamino)Carbonyl]-1,6-Diazabicyclo[3.2.1]Oct-6-Yl}Oxy)Sulfonyl]Oxidanide
CAS No.	1174020-24-6
Molecular Formula	C30H57N5O7S2
Molecular Weight	664.93 g/mol
Synonyms	Avibactam Tributylammonium Salt; (2S,5R)-7-Oxo-2-[(piperidin-4-ylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl hydrogen sulfate tributylammonium salt; NXL-104 Tributylammonium Salt; AVE1330A Tributylammonium Salt; N,N-Dibutylbutan-1-aminium [({(2S,5R)-7-oxo-2-[(piperidin-4-ylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl}oxy)sulfonyl]oxidanide; Avibactam TBA Salt; β-Lactamase Inhibitor Intermediate TBA Salt
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Our quality system includes rigorous in-process controls and comprehensive release testing. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support regulatory filings with ICH-stability data and can supply regulatory starting material (RSM) documentation packages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.