Description

Vaborbactam is a novel, non-β-lactam β-lactamase inhibitor of the boronic acid pharmacophore class, specifically designed to combat carbapenem-resistant bacterial infections. Its primary commercial value lies in its synergistic activity with meropenem, restoring the efficacy of this critical carbapenem antibiotic against resistant strains such as KPC-producing Klebsiella pneumoniae. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced antibacterial therapies, particularly for serious hospital-acquired infections where treatment options are limited.

Application

• Pharmaceutical API Synthesis: Used as the active pharmaceutical ingredient (API) in the fixed-dose combination drug Meropenem-Vaborbactam (marketed as Vabomere®).
• Antibacterial Drug Development: A key component in R&D for new combination therapies targeting multidrug-resistant Gram-negative bacteria.
• Microbiological Research: Employed in in vitro studies to understand and combat β-lactamase-mediated antibiotic resistance mechanisms.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in regulatory and laboratory settings.

Basic Information

Product Name	Vaborbactam
CAS No.	1360457-46-0
Molecular Formula	C12H16BNO5S
Molecular Weight	297.14 g/mol
Synonyms	(3R,6S)-2-Hydroxy-3-(2-thienylacetamido)-1,2-oxaborinane-6-acetic acid; RPX7009; Vabomere (combination product); (3R,6S)-3-[(2-Thienylacetyl)amino]-2-hydroxy-1,2-oxaborinane-6-acetic acid; Taniborbactam (structural analog, do not confuse); Boronic acid β-lactamase inhibitor RPX7009.
EINECS	Contact for details

Quality Control

Our Vaborbactam is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical R&D and API synthesis. Each batch is subjected to comprehensive analytical testing including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. The container should be kept tightly sealed in a dry environment upon each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.