Description

Piperacillin-Tazobactam Powder 8:1 is a critical combination antibiotic formulation where the broad-spectrum penicillin, piperacillin, is synergistically combined with the β-lactamase inhibitor, tazobactam, in an 8:1 ratio. This combination is essential for overcoming bacterial resistance, making it a powerful therapeutic agent against a wide range of serious infections. It is a fundamental raw material for pharmaceutical manufacturers developing injectable antibiotic formulations, particularly for hospital use. The product is supplied as a high-purity powder, meeting stringent standards for active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical API Manufacturing: Primary use as the active pharmaceutical ingredient in the production of sterile injectable antibiotic formulations.
• Hospital-Acquired Infection Treatment: Formulated into drugs for treating complicated intra-abdominal infections, nosocomial pneumonia, and septicemia caused by susceptible bacteria.
• Broad-Spectrum Antibiotic Preparations: Used in drugs targeting infections caused by Piperacillin-resistant, β-lactamase producing strains.
• Critical Care Medicine: Essential for formulators supplying antibiotics to intensive care units and surgical wards.
• Generic Drug Production: A key ingredient for manufacturers of generic parenteral antibiotic products.
• Research & Development: Serves as a reference standard and starting material for pharmaceutical R&D into new combination therapies or delivery systems.

Basic Information

Product Name	Piperacillin-Tazobactam Powder 8:1
CAS No.	123683-33-0
Molecular Formula	C23H27N5O7S (Piperacillin) · C10H12N4O5S (Tazobactam)
Molecular Weight	517.56 g/mol (Piperacillin) · 300.29 g/mol (Tazobactam)
Synonyms	Piperacillin Sodium and Tazobactam Sodium (8:1); Tazocin (Trade Name); Zosyn (Trade Name); Piperacillin/Tazobactam (8:1); Piperacillin-Tazobactam Combination; (2S,5R,6R)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide (8:1); PIPC/TAZ
EINECS	Contact for details

Quality Control

Our Piperacillin-Tazobactam Powder 8:1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Specifications are aligned with major pharmacopoeial guidelines. A Certificate of Analysis (COA) detailing purity, assay, impurity profile, and microbiological data is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Piperacillin to Tazobactam Ratio	7.8 : 1 to 8.2 : 1
Water Content (KF)	≤ 5.0%
pH (1% Solution)	5.0 - 7.0
Related Substances (HPLC)	Total Impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C Guidelines
Bacterial Endotoxins	< 0.05 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.