Description

Tazobactam is a potent, broad-spectrum β-lactamase inhibitor used in combination with certain penicillin antibiotics to overcome bacterial resistance. Its primary value lies in restoring the efficacy of antibiotics like piperacillin against β-lactamase-producing pathogens, making it a critical component in modern antimicrobial therapy. This compound is essential for pharmaceutical manufacturers developing combination injectable drugs for the treatment of serious hospital-acquired infections, including complicated intra-abdominal and urinary tract infections.

Application

• As a key active pharmaceutical ingredient (API) in the manufacture of injectable antibiotic combinations, most notably with piperacillin.
• For research and development of new antibacterial formulations to combat multi-drug resistant bacteria.
• In the production of finished pharmaceutical products under Good Manufacturing Practice (GMP) standards for global markets.
• As a reference standard in quality control laboratories for analytical method development and validation.
• For pharmacological studies investigating mechanisms of β-lactamase inhibition and bacterial resistance.

Basic Information

Product Name	Tazobactam
CAS No.	104862-31-9
Molecular Formula	C10H12N4O5S
Molecular Weight	300.29 g/mol
Synonyms	Tazobactam Acid; Tazobactamum; YTR 830H; CL 298741; (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; Piperacillin/Tazobactam component; β-Lactamase inhibitor Tazobactam
EINECS	Contact for details

Quality Control

Our Tazobactam is manufactured and tested to meet the stringent requirements of major pharmacopoeias, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, purity, and potency. A Certificate of Analysis (COA) detailing all test results is provided, ensuring full traceability and compliance with cGMP guidelines for pharmaceutical active ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	+172° to +182° (c=1 in water)
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.05 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.