Description

Avibactam Sodium is a potent, non-β-lactam β-lactamase inhibitor used in combination with β-lactam antibiotics to overcome antimicrobial resistance. This compound is critical for restoring the efficacy of existing antibiotics against multidrug-resistant bacterial infections. It is primarily required by pharmaceutical manufacturers and research institutions developing next-generation antibacterial therapies, particularly for hospital-acquired infections.

Application

• Active Pharmaceutical Ingredient (API) in combination antibiotic drugs (e.g., with ceftazidime or aztreonam).
• Research and development of novel antibacterial formulations to combat β-lactamase-producing pathogens.
• Manufacturing of sterile injectable pharmaceutical products for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI).
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Intermediate in the synthesis of more advanced β-lactamase inhibitor compounds.
• Component in microbiological media and susceptibility testing for antimicrobial resistance (AMR) surveillance.

Basic Information

Product Name	Avibactam Sodium
CAS No.	1192491-61-4
Molecular Formula	C7H10N3NaO6S
Molecular Weight	287.23 g/mol
Synonyms	NXL-104 Sodium; AVIBASTAT Sodium; (2S,5R)-7-Oxo-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Sodium Salt; Avibactam Sodium Salt; UNII-735T516Z99; β-lactamase inhibitor NXL104 sodium salt; Sodium (1R,2S,5R)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
EINECS	Contact for details

Quality Control

Our Avibactam Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and microbial limits testing, to ensure it meets stringent pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets Ph. Eur. 2.6.12 & 2.6.13
pH (5% solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.