Description

Methyl 4-Nitro-2-Trifluoromethylbenzoate is a high-value fluorinated aromatic ester building block, essential for advanced organic synthesis. Its unique structure, featuring both nitro and trifluoromethyl substituents, makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and as a substrate for developing novel catalytic methodologies.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where nitro and trifluoromethyl groups modify color and lightfastness properties.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorinated aromatic units into polymers to alter thermal, chemical, and surface properties.

Basic Information

Product Name	Methyl 4-Nitro-2-Trifluoromethylbenzoate
CAS No.	900254-47-9
Molecular Formula	C9H6F3NO4
Molecular Weight	249.14 g/mol
Synonyms	Methyl 4-nitro-2-(trifluoromethyl)benzoate; 2-Trifluoromethyl-4-nitrobenzoic Acid Methyl Ester; Benzoic acid, 4-nitro-2-(trifluoromethyl)-, methyl ester; Methyl 2-(trifluoromethyl)-4-nitrobenzoate; 4-Nitro-2-trifluoromethylbenzoic Acid Methyl Ester; Methyl α,α,α-trifluoro-4-nitro-o-toluate
EINECS	Contact for details

Quality Control

Our Methyl 4-Nitro-2-Trifluoromethylbenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.