Description

7,12-Dimethylbenz(A)Anthracene-Deoxyadenosine Adduct is a high-purity, structurally defined DNA adduct standard, critical for advanced toxicological and carcinogenesis research. This compound serves as a vital reference material for the precise detection and quantification of specific DNA damage caused by polycyclic aromatic hydrocarbon (PAH) metabolites. It is an essential tool for researchers and analytical laboratories in the fields of molecular toxicology, environmental health, and pharmaceutical safety assessment, enabling studies on mutagenesis, biomarker development, and metabolic activation pathways.

Application

• Biomarker Standard for Exposure Studies: Used as a calibration standard in mass spectrometry (LC-MS/MS, GC-MS) to quantify human exposure to benz(a)anthracene derivatives.
• Mechanistic Toxicology Research: Fundamental for investigating the metabolic activation of 7,12-Dimethylbenz(a)anthracene (DMBA) and its specific binding to deoxyadenosine in DNA.
• DNA Adductomics: A key reference compound in high-throughput screening methods aimed at profiling the complete spectrum of DNA damage.
• Carcinogenesis Model Validation: Employed to validate and calibrate analytical methods in animal and in vitro models of PAH-induced cancer.
• Quality Control in Reference Material Production: Serves as a purity benchmark for manufacturers of complex biochemical and diagnostic reference standards.
• Educational and Method Development: Used in academic and institutional settings for training and developing novel analytical protocols for DNA adduct detection.

Basic Information

Product Name	7,12-Dimethylbenz(A)Anthracene-Deoxyadenosine Adduct
CAS No.	99745-70-7
Molecular Formula	C31H29N5O4
Molecular Weight	535.60 g/mol
Synonyms	DMBA-dAdo Adduct; 7,12-DMBA-Deoxyadenosine Adduct; N6-(7,12-Dimethylbenz[a]anthracenyl)deoxyadenosine; DMBA-N6-dA; Benzo[rst]phenanthro[10,1-bcd]furan-5-one, 1,2,3,4,4a,4b,5,14b-octahydro-2,4b-dihydroxy-1,4b-dimethyl-7-(1-methylethyl)-, (1R,2S,4aR,4bS,10aS)-; Deoxyadenosine-7,12-Dimethylbenz[a]anthracene Adduct
EINECS	Contact for details

Quality Control

Every batch of our 7,12-Dimethylbenz(A)Anthracene-Deoxyadenosine Adduct is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from advanced chromatographic and spectroscopic methods. Our quality system is designed to meet the rigorous demands of research and analytical standard applications, ensuring reliable and reproducible performance in your critical studies.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. This material is light-sensitive and should be handled under appropriate conditions to maintain integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.