Description

Sodium Acetate-1-13C-2-D3 is a stable isotope-labeled compound, specifically a sodium salt of acetic acid where the carbon-1 position is enriched with carbon-13 and the methyl hydrogens are replaced by deuterium. This precise isotopic labeling makes it an essential internal standard and tracer for advanced analytical and metabolic research. It is primarily used by scientists and quality control professionals in pharmaceutical development, clinical diagnostics, and environmental analysis who require high-fidelity isotopic purity for accurate quantification and pathway elucidation.

Application

• Quantitative Nuclear Magnetic Resonance (qNMR) Spectroscopy: Serves as a primary quantitative standard for the precise determination of analyte concentrations in complex mixtures.
• Mass Spectrometry (MS) Internal Standard: Used in LC-MS and GC-MS workflows to correct for matrix effects and instrument variability, ensuring accurate quantification of acetate and related metabolites.
• Metabolic Flux Analysis (MFA): Acts as a tracer to study central carbon metabolism (e.g., glycolysis, TCA cycle) in biological systems, providing insights into cellular physiology and disease mechanisms.
• Pharmaceutical Impurity Profiling and PK/PD Studies: Employed in the development and validation of methods to track drug metabolites and assess pharmacokinetics/pharmacodynamics.
• Clinical Diagnostic Assays: Used as a calibrant or reference material in in-vitro diagnostic tests measuring acetate or short-chain fatty acid levels.
• Environmental and Food Safety Testing: Applied as a labeled standard in the analysis of volatile fatty acids in environmental samples or food products.

Basic Information

Product Name	Sodium Acetate-1-13C-2-D3
CAS No.	102212-93-1
Molecular Formula	C13CH3COONa
Molecular Weight	84.05 g/mol (for 13C12H3COONa)
Synonyms	Acetic-1-13C-2,2,2-d3 acid sodium salt; Sodium [1-13C, 2,2,2-2H3]acetate; [1-13C, 2,2,2-2H3]-Sodium acetate; 13C1, D3-Sodium acetate; Sodium Acetate (13C1, D3); Sodium [13C]acetate-d3; Labeled Sodium Acetate
EINECS	Contact for details

Quality Control

Every batch of Sodium Acetate-1-13C-2-D3 is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure it meets the high standards required for research and diagnostic applications. Key parameters verified include isotopic purity (enrichment of 13C and D), chemical purity, and absence of interfering impurities. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from NMR, MS, and HPLC analyses.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which can affect stability and accurate weighing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
13C Isotopic Enrichment	≥ 99 atom %
Deuterium (D) Enrichment	≥ 98 atom % (per D3 position)
Chemical Purity (NMR)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.