Description

Tracheal Cytotoxin, Bordetella Pertussis CAS NO 118013-66-4 is a peptidoglycan-derived virulence factor specifically produced by the bacterium *Bordetella pertussis*, the causative agent of whooping cough. This compound is critical for researchers studying the molecular pathogenesis of pertussis and the host's inflammatory immune response to bacterial infection. It is primarily utilized in life science research, vaccine development, and the pharmaceutical industry for investigating novel therapeutic and prophylactic strategies.

Application

• Pathogenesis Research: Key reagent for studying the specific cytotoxic effects of *B. pertussis* on ciliated epithelial cells in the respiratory tract.
• Immunology Studies: Used to investigate innate immune responses, including the induction of nitric oxide synthase and interleukin-1 production.
• Vaccine Development & Evaluation: Serves as a critical antigen and tool for assessing vaccine efficacy and host immune response in preclinical models.
• Pharmaceutical Screening: Employed in high-throughput assays to identify potential anti-inflammatory or anti-toxin compounds targeting pertussis pathology.
• Diagnostic Tool Development: Used in the development and calibration of immunoassays and other diagnostic methods for pertussis infection.
• Academic & Institutional Research: Essential for university and government laboratories focused on bacteriology, respiratory diseases, and host-pathogen interactions.

Basic Information

Product Name	Tracheal Cytotoxin, Bordetella Pertussis
CAS No.	118013-66-4
Molecular Formula	C42H68N8O19
Molecular Weight	989.04 g/mol
Synonyms	Tracheal Cytotoxin; TCT; Bordetella Pertussis Tracheal Cytotoxin; Pertussis Tracheal Cytotoxin; N-Acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-alanyl-γ-glutamyl-meso-diaminopimelyl-alanine; GlcNAc-anhMurNAc-L-Ala-γ-D-Glu-meso-A2pm-D-Ala; NAG-NAM Peptide; Peptidoglycan Monomer (B. pertussis-specific)
EINECS	Contact for details

Quality Control

Our Tracheal Cytotoxin, Bordetella Pertussis is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and endotoxin level testing. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep desiccated at -70°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (Cell-based assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/μg
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.