Description

Dihydroxyphenylalanine, L-3,4-[Ring 2,5,6-3H] is a tritium-labeled, high-specific-activity derivative of L-DOPA, a critical amino acid precursor in neurotransmitter biosynthesis. This radiolabeled compound is essential for advanced research requiring precise tracking and quantification in biological systems. It is primarily utilized by pharmaceutical R&D teams, neurochemistry researchers, and clinical diagnostic developers for tracer studies, metabolic pathway analysis, and receptor binding assays.

Application

• Neuropharmacology Research: As a tracer for studying the biosynthesis, metabolism, and transport of dopamine and other catecholamines in the central nervous system.
• Drug Discovery & Development: Used in in vitro and in vivo assays to investigate the mechanism of action, pharmacokinetics, and biodistribution of potential therapeutics for Parkinson's disease and other neurological disorders.
• Biochemical Tracer Studies: Employed in enzymatic assays and metabolic pathway analysis to elucidate the kinetics of tyrosine hydroxylase and aromatic L-amino acid decarboxylase.
• Autoradiography & Imaging: Serves as a probe in receptor autoradiography and other imaging techniques to localize and quantify dopaminergic pathways and binding sites.
• Clinical Research: Applied in specialized clinical studies to understand catecholamine-related disorders and to develop diagnostic methods.

Basic Information

Product Name	Dihydroxyphenylalanine, L-3,4-[Ring 2,5,6-3H]
CAS No.	18683-98-2
Molecular Formula	C9H11NO4 (³H-labeled)
Molecular Weight	Contact for details (varies with specific activity)
Synonyms	L-[Ring-2,5,6-³H]DOPA; 3,4-Dihydroxy-L-[2,5,6-³H]phenylalanine; Tritiated L-DOPA; L-3,4-Dihydroxyphenyl[2,5,6-³H]alanine; (2S)-2-Amino-3-(3,4-dihydroxy[2,5,6-³H]phenyl)propanoic acid; ³H-L-DOPA; Radioactive L-DOPA; L-DOPA (tritium labeled)
EINECS	Contact for details

Quality Control

Every batch of our tritium-labeled L-DOPA is manufactured and controlled to meet the stringent requirements of research and preclinical applications. Quality is assured through rigorous analytical testing, including determination of radiochemical purity and specific activity via HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA), detailing purity, concentration, solvent system, and analytical methods, is provided with each shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). For long-term storage, keep the solution in the original container, sealed under an inert atmosphere such as argon or nitrogen, in a dedicated freezer. Always follow local regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	20-80 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Concentration	1 mCi/mL (Solvent: Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.