Description

Guanidine-15N3 Hydrochloride is a stable isotope-labeled derivative of guanidine hydrochloride, where all three nitrogen atoms are enriched with the 15N isotope. This compound is essential as a high-purity internal standard and reagent in quantitative mass spectrometry and NMR spectroscopy, ensuring precise and accurate analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and academic institutions engaged in proteomics, metabolomics, and pharmacokinetic studies.

Application

• Internal standard for the quantitative analysis of guanidine and related compounds via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Metabolic pathway tracing and flux analysis in biological systems using NMR spectroscopy.
• Protein denaturation and refolding studies in biophysical chemistry and structural biology.
• Reagent in the synthesis of isotopically labeled pharmaceuticals and bioactive molecules.
• Use in proteomics for the quantification of post-translational modifications like citrullination.
• Critical component in method development and validation for regulatory bioanalysis (GLP/GCP).

Basic Information

Product Name	Guanidine-15N3 Hydrochloride
CAS No.	121616-39-5
Molecular Formula	CH615N3•HCl
Molecular Weight	97.53 g/mol
Synonyms	Guanidine Hydrochloride-15N3; [15N3]-Guanidine Hydrochloride; Guanidine-15N3 Monohydrochloride; Aminoformamidine-15N3 Hydrochloride; Carbamamidine-15N3 Hydrochloride; Isotope Labeled Guanidine HCl; Guanidine-15N3 HCl; Guanidinium-15N3 Chloride
EINECS	Contact for details

Quality Control

Our Guanidine-15N3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including isotopic enrichment verification by NMR and MS, chemical purity assessment by HPLC, and confirmation of critical parameters. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N3)	≥ 98 atom % 15N
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.