Description

n-(Guanin-8-Yl)-n-Acetyl-2-Aminofluorene CAS NO 14490-85-8 is a specialized heterocyclic aromatic compound that serves as a critical biochemical tool and research standard. This compound is valued for its role as a well-characterized DNA adduct, enabling advanced studies in mutagenesis, carcinogenesis, and molecular toxicology. It is primarily required by research institutions, pharmaceutical R&D laboratories, and analytical testing facilities focused on genetic toxicology, biomarker discovery, and the development of analytical reference standards for forensic and environmental analysis.

Application

• Biochemical Research Standard: Used as a high-purity reference material for calibrating analytical instruments in DNA adduct quantification studies.
• Genetic Toxicology Studies: Serves as a model compound for investigating the mechanisms of chemical mutagenesis and carcinogenesis.
• Analytical Method Development: Employed in the validation and development of sensitive detection methods like LC-MS/MS and HPLC for DNA damage products.
• Biomarker Research: Acts as a specific biomarker in studies assessing exposure to aromatic amines and their metabolic activation pathways.
• Pharmaceutical Safety Assessment: Utilized in preclinical studies to understand potential genotoxic impurities and their interaction with genetic material.
• Academic Research: Fundamental tool in university laboratories for teaching and research in bioorganic chemistry and molecular biology.

Basic Information

Product Name	n-(Guanin-8-Yl)-n-Acetyl-2-Aminofluorene
CAS No.	14490-85-8
Molecular Formula	C21H16N6O2
Molecular Weight	384.39 g/mol
Synonyms	N-Acetyl-N-(guanin-8-yl)-2-aminofluorene; 8-(N-Acetyl-2-fluorenylamino)guanine; N-Acetoxy-2-acetylaminofluorene-Guanine Adduct; Guanine C8-AAF Adduct; AAF-Guanine Adduct; N-(Guanin-8-yl)-N-acetyl-2-aminofluorene; DNA Adduct of 2-Acetylaminofluorene
EINECS	Contact for details

Quality Control

Our n-(Guanin-8-Yl)-n-Acetyl-2-Aminofluorene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant standards for research chemicals, and our quality system is designed to meet the stringent requirements of analytical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.