Description

3'-Azido-3'-Deoxyarabinothymidine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate and building block for the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, reliable intermediates for advanced therapeutic programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Antiviral Research: Used in the development and study of novel compounds targeting HIV, hepatitis, and other viral infections.
• Anticancer Agent Development: Investigated as a precursor for prodrugs and compounds designed to inhibit cancer cell proliferation.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair mechanisms.
• Prodrug Synthesis: Utilized in creating more bioavailable or targeted forms of therapeutic nucleosides.
• Labeled Compound Preparation: Serves as a starting material for synthesizing isotopically labeled analogs for pharmacokinetic and metabolic studies.

Basic Information

Product Name	3'-Azido-3'-Deoxyarabinothymidine
CAS No.	99614-77-4
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	3'-Azido-3'-deoxythymidine; 3'-Azido-2',3'-dideoxythymidine; AZT Arabinoside; 1-((2R,4S,5S)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 3'-N3-Thymidine; Azidothymidine Arabinoside
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxyarabinothymidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.