Description

L-Tryptophan (α-15N) is a stable isotope-labeled derivative of the essential amino acid L-Tryptophan, where the alpha nitrogen atom is enriched with the 15N isotope. This compound is a critical tool for advanced research in metabolism, protein dynamics, and nutritional studies, providing a non-radioactive tracer for precise quantification and pathway elucidation. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers engaged in mass spectrometry, NMR spectroscopy, and stable isotope probing.

Application

• Biomedical Research Tracer: Used in metabolic flux analysis and protein turnover studies to track nitrogen incorporation and amino acid metabolism in vivo and in vitro.
• Pharmaceutical Development: Serves as an internal standard in quantitative bioanalysis (LC-MS/MS) for drug pharmacokinetics and biomarker discovery related to tryptophan pathways.
• Nutritional Science: Employed in human and animal studies to investigate protein synthesis, amino acid requirements, and the metabolic fate of dietary tryptophan.
• Neurochemical Research: Facilitates studies on the synthesis and regulation of neurotransmitters like serotonin, where the tryptophan metabolic pathway is central.
• Proteomics & Structural Biology: Used in NMR spectroscopy for protein structure determination and dynamics by incorporating the 15N-labeled amino acid into recombinant proteins.

Basic Information

Product Name	L-Tryptophan (α-15N)
CAS No.	99404-62-3
Molecular Formula	C₁₁H₁₂N¹⁵NO₂
Molecular Weight	205.22 g/mol (for ¹⁵N labeled form)
Synonyms	(S)-2-Amino-3-(1H-indol-3-yl)propanoic-α-15N acid; L-α-15N-Tryptophan; Tryptophan-α-15N; (S)-Tryptophan-α-15N; 1H-Indole-3-alanine-α-15N; 15N Labeled L-Tryptophan; Trypto-α-15N; 15N-L-TRP
EINECS	Contact for details

Quality Control

Our L-Tryptophan (α-15N) is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % ¹⁵N), chemical purity (by HPLC), chiral purity, and spectroscopic confirmation. We support research and GMP-grade requirements with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % ¹⁵N)	≥ 98%
Optical Rotation	[α]²⁰D = -30.0° to -34.0° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.