Description

Venlafaxine Hydrochloride is the hydrochloride salt form of venlafaxine, a bicyclic phenylethylamine derivative. This active pharmaceutical ingredient (API) is a critical component in the formulation of antidepressant medications, specifically serotonin-norepinephrine reuptake inhibitors (SNRIs). It is primarily required by pharmaceutical manufacturers and research institutions for the production of generic and branded antidepressant drugs. The compound is supplied to meet the stringent quality standards demanded by global regulatory bodies.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant tablets and capsules.
• Generic Drug Formulation: Serves as a key component for companies producing bioequivalent versions of SNRI medications.
• Clinical Research: Utilized in preclinical and clinical studies for developing new therapeutic applications or dosage forms.
• Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and method validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for finished dosage form production.

Basic Information

Product Name	Venlafaxine Hydrochloride
CAS No.	99300-78-4
Molecular Formula	C17H27NO2 • HCl
Molecular Weight	313.86 g/mol (as hydrochloride salt)
Synonyms	Venlafaxine HCl; (±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride; (R/S)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride; Effexor (trade name active ingredient); WY-45,030; CP-36,584-1
EINECS	Contact for details

Quality Control

Our Venlafaxine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure compliance with major pharmacopoeial standards such as USP and EP. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting purity, identity, and impurity profiles. We ensure traceability and supply chain integrity to meet the rigorous demands of pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.15%; Total impurities ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.