Description

(+)-(3R,4R)-Bis(Diphenylphosphino)-1-Benzylpyrrolidine is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. This compound matters because it enables precise stereochemical control in transition metal-catalyzed reactions, leading to the efficient synthesis of enantiomerically pure pharmaceuticals and fine chemicals. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric Cross-Coupling Reactions: Used in C-C and C-X bond-forming reactions to create chiral centers with high enantiomeric excess.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, such as chiral amines and alcohols.
• Agrochemical Synthesis: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.
• Fine Chemical Production: Facilitates the synthesis of complex, high-value chiral molecules for flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(+)-(3R,4R)-Bis(Diphenylphosphino)-1-Benzylpyrrolidine
CAS No.	99135-95-2
Molecular Formula	C35H33NP2
Molecular Weight	529.59 g/mol
Synonyms	(R,R)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine; (3R,4R)-1-Benzyl-3,4-bis(diphenylphosphanyl)pyrrolidine; (R,R)-Benzyl-BisP*; (R,R)-BenzP*; (R,R)-1-Benzyl-2,5-bis(diphenylphosphino)pyrrolidine; (R,R)-Bn-BisP*; ChiraPhos Bn; (R,R)-Benzyl Pyrrolidine Bisphosphine Ligand
EINECS	Contact for details

Quality Control

Our (+)-(3R,4R)-Bis(Diphenylphosphino)-1-Benzylpyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for catalytic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and impurity profile. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and humidity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.