Description

(1R,2S)-(-)-trans-2-Phenyl-1-Cyclohexanol is a high-purity chiral cyclohexanol derivative, serving as a critical chiral building block and resolving agent in asymmetric synthesis. Its defined stereochemistry is essential for imparting specific optical activity to target molecules, enabling the production of enantiomerically pure intermediates. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used to develop and synthesize novel chiral ligands for transition metal catalysis, enhancing stereoselectivity in C-C bond formation and hydrogenation reactions.
• Chiral Resolving Agent: Employed for the optical resolution of racemic mixtures of acids, amines, and other chiral compounds via diastereomeric salt formation or derivative synthesis.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and pesticides with improved efficacy and environmental profile.
• Advanced Material Research: Utilized in the development of chiral liquid crystals, polymers, and sensors where molecular handedness dictates functional properties.
• Academic & Process Chemistry: A valuable tool for methodological development in organic synthesis and for scaling up enantioselective processes from lab to pilot plant.

Basic Information

Product Name	(1R,2S)-(-)-trans-2-Phenyl-1-Cyclohexanol
CAS No.	98919-68-7
Molecular Formula	C12H16O
Molecular Weight	176.26 g/mol
Synonyms	(-)-trans-2-Phenylcyclohexanol; (1R,2S)-2-Phenylcyclohexan-1-ol; (1R,2S)-(-)-2-Phenyl-1-cyclohexanol; trans-(-)-2-Phenylcyclohexanol; (1R,2S)-2-Phenyl-1-cyclohexanol; L-erythro-2-Phenylcyclohexanol; (-)-(1R,2S)-2-Phenylcyclohexanol
EINECS	Contact for details

Quality Control

Our (1R,2S)-(-)-trans-2-Phenyl-1-Cyclohexanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound is stable under these conditions but should be kept under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Specific range available on COA
Optical Rotation [α]	Specific value available on COA
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.