Description

15-Deoxymethylspergualin is a synthetic derivative of the natural product spergualin, functioning as a potent immunosuppressive agent. Its primary value lies in its ability to inhibit key enzymes involved in immune cell proliferation, making it a critical research compound for studying autoimmune diseases and organ transplantation. This product is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on immunology and drug discovery. The compound is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Immunosuppressive Research: A key tool for in vitro and in vivo studies of autoimmune disorders, graft-versus-host disease (GvHD), and transplant rejection mechanisms.
• Pharmaceutical Development: Serves as a reference standard and a critical building block in the synthesis of novel immunomodulatory drug candidates.
• Biochemical Pathway Analysis: Used to investigate the inhibition of specific molecular targets, such as inducible nitric oxide synthase (iNOS) and other enzymes involved in inflammatory responses.
• Preclinical Studies: Employed in animal models to evaluate efficacy and pharmacokinetics of next-generation immunosuppressive therapies.

Basic Information

Product Name	15-Deoxymethylspergualin
CAS No.	98629-44-8
Molecular Formula	C₁₇H₃₇N₇O₄
Molecular Weight	403.53 g/mol
Synonyms	15-Deoxyspergualin; (-)-15-Deoxyspergualin; Gusperimus; 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione; Spanidin; NKT-01; DSG; Deoxyspergualin
EINECS	Contact for details

Quality Control

Our 15-Deoxymethylspergualin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For cGMP-grade material or specific pharmacopeial standards (USP/EP), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.