Description

Valclavam is a semi-synthetic β-lactamase inhibitor, structurally related to clavulanic acid, designed to enhance the efficacy of β-lactam antibiotics. Its primary value lies in its potent ability to inactivate a broad spectrum of β-lactamase enzymes, thereby protecting co-administered antibiotics from degradation and restoring their activity against resistant bacterial strains. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced combination therapies to combat antimicrobial resistance.

Application

• As a key pharmaceutical intermediate in the synthesis of advanced β-lactamase inhibitor combinations.
• For research and development of new antibiotic formulations targeting multi-drug resistant bacteria.
• In the production of veterinary medicines to enhance the spectrum and potency of animal health antibiotics.
• As a reference standard in analytical laboratories for quality control and method development.
• For biochemical studies investigating the mechanisms of β-lactamase inhibition and bacterial resistance.

Basic Information

Product Name	Valclavam
CAS No.	98359-78-5
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; Valclavam; Clavulanic acid derivative; β-lactamase inhibitor intermediate; 98359-78-5; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S,5R)-
EINECS	Contact for details

Quality Control

Our Valclavam is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D and manufacturing. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.