Description

Levomilnacipran is the pharmacologically active enantiomer of the serotonin-norepinephrine reuptake inhibitor (SNRI) milnacipran. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and consistency of finished pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antidepressant medications. Our supply is characterized by stringent quality control and reliable scalability to meet global project demands.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of antidepressant drugs targeting major depressive disorder (MDD).
• Clinical Research: Used in preclinical and clinical studies to investigate neurological pathways and therapeutic efficacy.
• Formulation Development: Serves as a reference standard and key component in developing various dosage forms such as tablets and capsules.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods.
• Process Chemistry: Used in scaling up and optimizing synthetic routes for commercial production.

Basic Information

Product Name	Levomilnacipran
CAS No.	96847-55-1
Molecular Formula	C15H22N2O
Molecular Weight	246.35 g/mol
Synonyms	(1S,2R)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; F2695; (1S,2R)-Milnacipran; Levomilnacipran Hydrochloride (salt form); Fetzima™ (brand name for finished product); (1S,2R)-2-[(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide]; (1S,2R)-2-(Aminomethyl)-1-phenyl-N,N-diethylcyclopropanecarboxamide
EINECS	Contact for details

Quality Control

Our Levomilnacipran is manufactured under strict quality management systems. Every batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with typical purity exceeding 99.0% by HPLC. Comprehensive testing includes chiral purity, identification, assay, and control of specified impurities and residual solvents. A Certificate of Analysis (COA) documenting all test results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 99.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.5%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.10% Total impurities ≤ 0.50%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.