Description

Dl-Glutamic-5-13C Acid is a stable isotope-labeled analog of glutamic acid, where the carbon-13 (13C) isotope is specifically incorporated at the 5-position. This precise labeling is critical for applications requiring high-fidelity metabolic and biochemical pathway tracing. It is an essential research-grade material for scientists in pharmaceutical development, nutritional studies, and advanced analytical chemistry who require uncompromised isotopic purity and chemical stability for their tracer experiments.

Application

• Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to study central carbon metabolism, glycolysis, and the TCA cycle in cell cultures, tissues, and microorganisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in mass spectrometry for the accurate quantification of glutamic acid and related metabolites in biological samples, enhancing data reliability.
• Nutritional Research: Employed in studies investigating amino acid absorption, protein synthesis, and nitrogen metabolism using isotope ratio mass spectrometry (IRMS) or NMR spectroscopy.
• Biochemical Pathway Elucidation: Facilitates the detailed mapping of biosynthetic pathways and neurotransmitter cycling in neuroscience and plant biochemistry research.
• Stable Isotope Labeling in Cell Culture (SILAC): Can be utilized in specialized SILAC protocols for proteomic studies requiring heavy amino acid labels.
• Quality Control Reference Standard: Acts a high-purity certified reference material (CRM) for calibrating analytical instruments in food, clinical, and environmental testing laboratories.

Basic Information

Product Name	Dl-Glutamic-5-13C Acid
CAS No.	95388-01-5
Molecular Formula	C413CH9NO4
Molecular Weight	148.11 g/mol (for 13C1 isotopologue)
Synonyms	(±)-Glutamic-5-13C Acid; DL-Glutamic-5-13C Acid; (RS)-Glutamic-5-13C Acid; 2-Aminopentanedioic-5-13C Acid; 13C1-Glutamic Acid; Glutamic Acid-5-13C; 5-13C-DL-Glutamic Acid; 1,3-13C-Glutamic Acid (common misnomer)
EINECS	Contact for details

Quality Control

Our Dl-Glutamic-5-13C Acid is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity, and chiral purity. We adhere to relevant standards for high-purity biochemicals, and custom specifications for GMP or other regulatory frameworks can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at position 5
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	N/A (racemic mixture)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.