Description

2,4-Difluorocinnamic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for introducing the difluorophenyl moiety into target molecules, enabling the fine-tuning of physicochemical properties. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the difluorophenyl group enhances bioactivity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated organic semiconductors and liquid crystal compounds.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for incorporation into peptides or use as a linker in bioconjugation chemistry.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new fluorination reactions and catalytic processes.

Basic Information

Product Name	2,4-Difluorocinnamic Acid
CAS No.	94977-52-3
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(2E)-3-(2,4-Difluorophenyl)prop-2-enoic acid; trans-2,4-Difluorocinnamic Acid; (E)-3-(2,4-Difluorophenyl)acrylic acid; 2,4-Difluoro-trans-cinnamic Acid; β-(2,4-Difluorophenyl)acrylic Acid; 2,4-DFCA; NSC 405124
EINECS	Contact for details

Quality Control

Our 2,4-Difluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should minimize prolonged exposure to light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.