Description

6-Hydroxymelatonin Glucuronide is a key conjugated metabolite of melatonin, formed via glucuronidation in the liver. This compound is of significant interest for its role in metabolic pathway studies and as a critical reference standard in analytical chemistry. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for method development, validation, and bioanalytical research.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of melatonin and its metabolites in drug metabolism and pharmacokinetic (DMPK) studies.
• Biomarker Research: Essential for developing and validating analytical methods (e.g., LC-MS/MS, HPLC) to detect and measure melatonin metabolic profiles in biological fluids for clinical research.
• Enzyme Activity Assays: Serves as a specific substrate or product in studies investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Diagnostic Kit Development: Employed in the manufacturing and calibration of immunoassay kits designed to assess circadian rhythm disorders or sleep-related biomarkers.
• Toxicology and Safety Assessment: Used in studies to understand the detoxification and excretion pathways of melatonin and related indole compounds.
• Academic and Institutional Research: A vital tool for universities and research institutes conducting fundamental research in endocrinology, neuroscience, and chronobiology.

Basic Information

Product Name	6-Hydroxymelatonin Glucuronide
CAS No.	94840-69-4
Molecular Formula	C18H22N2O8
Molecular Weight	394.38 g/mol
Synonyms	6-Hydroxy Melatonin Glucuronide; 6-OH-Melatonin Glucuronide; N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-O-β-D-glucopyranuronosyl-hydroxylamine; Melatonin 6-Glucuronide; 6-Glucuronyl Melatonin; 6-Hydroxy-N-acetyl-5-methoxytryptamine Glucuronide
EINECS	Contact for details

Quality Control

Our 6-Hydroxymelatonin Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures the material is suitable for use as a high-purity reference standard in regulated and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing at -20°C. The product is light-sensitive; keep the original container sealed in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.