Description

Citrulline-C13 is a stable isotope-labeled analog of the amino acid L-citrulline, where a carbon-13 atom replaces the natural carbon-12 at a specific position. This high-purity compound is essential for advanced research requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and manufacturers in the pharmaceutical, nutritional, and life science research sectors for applications in mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of endogenous citrulline levels in complex biological matrices like plasma, serum, and tissue samples.
• Metabolic Pathway Analysis: Used as a tracer to study the urea cycle, nitric oxide synthesis, and arginine metabolism in preclinical and clinical research settings.
• Drug Metabolism Studies (DMPK): Employed in pharmacokinetic and pharmacodynamic research to track the metabolism of drug candidates and understand their biochemical fate.
• Clinical Diagnostics Development: A critical component in the development and calibration of LC-MS/MS assays for diagnosing inborn errors of metabolism and monitoring disease states.
• Nutritional Research: Used to investigate the bioavailability, absorption, and utilization of citrulline and related amino acids in dietary and sports nutrition studies.
• Biomarker Discovery & Validation: Facilitates the precise measurement of citrulline as a potential biomarker for conditions affecting liver function, gut health, and cardiovascular systems.

Basic Information

Product Name	Citrulline-C13
CAS No.	94740-46-2
Molecular Formula	C6H1313CN3O3
Molecular Weight	~176.17 g/mol (exact mass depends on 13C position)
Synonyms	L-Citrulline-13C; (S)-2-Amino-5-([13C]carbamimidamido)pentanoic acid; Isotope-labeled L-Citrulline; Carbon-13 labeled Citrulline; Stable Isotope of Citrulline; Citrulline Internal Standard; Ureidonorvaline-13C
EINECS	Contact for details

Quality Control

Our Citrulline-C13 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and absence of key impurities. We adhere to standards relevant for research and diagnostic use, ensuring reliability and consistency for your critical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and weighing accuracy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Isotopic Enrichment (Atom % 13C)	≥ 99% (Position-specific)
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]D20: +23.0° to +25.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.