Description

2'-Deoxyguanosine, [8-14C] is a carbon-14 radiolabeled nucleoside analog, specifically labeled at the C8 position of the guanine base. This compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to track the incorporation and fate of deoxyguanosine in biological systems. It is a critical tool for scientists in pharmaceutical R&D, biochemistry, and molecular biology, particularly for investigating DNA synthesis, repair mechanisms, and the metabolism of nucleoside-based therapeutics.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of nucleoside analogs and related compounds.
• DNA Synthesis and Repair Research: Employed to investigate the pathways and kinetics of DNA replication and repair mechanisms in vitro and in cellular models.
• Biochemical Pathway Analysis: Facilitates the elucidation of purine and nucleotide salvage pathways by tracking the labeled moiety through enzymatic reactions.
• Development of Diagnostic Assays: Serves as a key component in the development of sensitive assays for measuring enzymatic activities, such as those of kinases or polymerases.
• Autoradiography and Imaging Studies: Provides the radioactive signal necessary for autoradiographic localization of nucleotide incorporation in tissues or gels.
• Stability and Degradation Studies: Used to assess the metabolic stability and identify potential degradation products of guanosine-based compounds.

Basic Information

Item	Detail
Product Name	2'-Deoxyguanosine, [8-14C]
CAS No.	94504-68-4
Molecular Formula	C₁₀H₁₃¹⁴CN₅O₄
Molecular Weight	Contact for details
Synonyms	8-14C-2'-Deoxyguanosine; [8-14C]-2'-Deoxyguanosine; 2'-Deoxy[8-14C]guanosine; Guanosine, 2'-deoxy-, 8-14C-labeled; dG-[8-14C]; 2'-Deoxyguanosine-8-14C; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-14C-6,9-dihydro-1H-purin-6-one
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxyguanosine, [8-14C] is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, purity by HPLC, and analytical chromatograms are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is light-sensitive (store away from light). For long-term storage, solutions should be prepared in appropriate buffers and stored frozen. Always follow local radiation safety regulations for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (radiochemical)
Specific Activity	Contact for details (mCi/mmol)
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.