Description

(1,2,6,7-3H[N])-Progesterone is a tritium-labeled derivative of the essential steroid hormone progesterone, specifically designed for research and analytical applications. This high-specific-activity compound is critical for sensitive detection and quantification in metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in endocrinology, drug development, and receptor binding assays.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of progesterone and related compounds.
• Receptor Binding Assays: Essential for in vitro studies to characterize the binding affinity and kinetics of compounds to progesterone receptors (PR).
• Biochemical Pathway Analysis: Enables the tracking and quantification of progesterone in complex biological systems and metabolic pathways.
• Analytical Method Development and Validation: Serves as an internal standard or reference material in advanced analytical techniques like Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Endocrine Disruptor Research: Used in studies investigating the interaction of environmental chemicals with hormonal systems.
• Clinical Research: Supports investigations into progesterone-related physiological processes and disorders.

Basic Information

Product Name	(1,2,6,7-3H[N])-Progesterone
CAS No.	94391-12-5
Molecular Formula	C21H263H4O2
Molecular Weight	~ 322.5 g/mol (for 3H4 labeled)
Synonyms	[1,2,6,7-3H]Progesterone; Progesterone-1,2,6,7-3H4; Tritiated Progesterone; NSC 9704; 4-Pregnene-3,20-dione-1,2,6,7-3H4; (3H)Progesterone; 1,2,6,7-Tetratritio-progesterone
EINECS	Contact for details

Quality Control

Every batch of (1,2,6,7-3H[N])-Progesterone is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure high radiochemical purity and specific activity, critical for sensitive research applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as radiochemical purity (by HPLC), specific activity, chemical purity, and solvent composition. Our quality commitment aligns with the standards expected in pharmaceutical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label. Due to its highly volatile nature (tritium gas potential) and light-sensitive properties, appropriate laboratory safety protocols for handling radioactive materials must be followed. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	60 - 100 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol or Toluene/Ethanol (as specified)
Concentration	1 mCi/mL (Contact for other concentrations)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.