Description

3'-Epi-Idoxuridine is a nucleoside analogue and a stereoisomer of the antiviral compound idoxuridine. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a biochemical tool and a reference standard. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in antiviral drug discovery, metabolic pathway studies, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and analytical method validation in drug development.
• Biochemical Research: Serves as a crucial tool for studying nucleoside metabolism, enzyme specificity, and the structure-activity relationships (SAR) of antiviral agents.
• Antiviral Mechanism Studies: Employed in in-vitro research to investigate the mechanisms of action and resistance of thymidine analogue-based therapies.
• Process Development & Impurity Profiling: Acts as a key impurity marker or intermediate in the synthesis and purification processes of related active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and virology.

Basic Information

Product Name	3'-Epi-Idoxuridine
CAS No.	93780-25-7
Molecular Formula	C9H11IN2O5
Molecular Weight	354.10 g/mol
Synonyms	1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione; 5-Iodo-2'-deoxy-3'-epiuridine; 3'-epi-IDU; 3'-Epi-5-iodo-2'-deoxyuridine; 3'-Epi-IDUR; (2'R)-5-Iodo-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 3'-Epi-Idoxuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.