Description

2-(4-Fluorophenyl)-2-Methylpropanoic Acid is a high-purity fluorinated organic building block of significant commercial interest. This compound serves as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, valued for its structural motif that can impart desirable biological activity and metabolic stability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutics containing a fluorinated arylpropanoic acid core.
• Agrochemical Synthesis: Used in the development of modern herbicides and pesticides, where the fluorine atom enhances lipophilicity and biological efficacy.
• Liquid Crystal Materials: Acts as a precursor or side-chain component in the synthesis of fluorinated liquid crystals for display technologies.
• Polymer Science: Employed as a monomer or modifier to introduce fluorine-containing groups into polymers, altering their surface properties, chemical resistance, and stability.
• Organic Synthesis & Research: A versatile building block for Suzuki coupling, esterification, and amidation reactions in medicinal and process chemistry R&D.
• Material Science: Investigated for use in the creation of advanced organic electronic materials and coatings.

Basic Information

Product Name	2-(4-Fluorophenyl)-2-Methylpropanoic Acid
CAS No.	93748-19-7
Molecular Formula	C10H11FO2
Molecular Weight	182.19 g/mol
Synonyms	p-Fluoro-α,α-dimethylphenylacetic Acid; 4-Fluoro-α,α-dimethylbenzenecetic Acid; 2-(p-Fluorophenyl)-2-methylpropanoic Acid; 2-Methyl-2-(4-fluorophenyl)propanoic Acid; 4-Fluoro-α,α-dimethylbenzeneacetic Acid; FLUORIBUFEN; (4-Fluorophenyl)-2-methylpropanoic Acid
EINECS	Contact for details

Quality Control

Our 2-(4-Fluorophenyl)-2-Methylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	95°C - 100°C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.