Description

S-Venlafaxine-Di-p-Toluoyl-L-Tartrate Salt (2:1) CAS NO 93471-25-1 is a high-purity, non-racemic salt form of the active pharmaceutical ingredient Venlafaxine, specifically engineered for advanced pharmaceutical synthesis and research. This compound is critical for the development of enantiomerically pure therapeutics, offering superior control over stereochemistry and pharmacokinetic properties. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers focused on developing novel antidepressants and central nervous system (CNS) drugs.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of enantiomerically pure (S)-Venlafaxine hydrochloride.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the efficacy and safety profile of the single enantiomer.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process optimization and commercial-scale manufacturing of serotonin-norepinephrine reuptake inhibitors (SNRIs).
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control (HPLC, chiral analysis) in regulatory submissions.
• Asymmetric Synthesis Studies: Valuable for academic and industrial research focused on chiral resolution techniques and salt formation strategies.

Basic Information

Product Name	S-Venlafaxine-Di-p-Toluoyl-L-Tartrate Salt (2:1)
CAS No.	93471-25-1
Molecular Formula	C52H60N2O12
Molecular Weight	905.04 g/mol
Synonyms	(1S,2S)-1-(4-Methoxyphenyl)-2-(1-hydroxycyclohexyl)ethylamine (2:1) salt with (2R,3R)-2,3-Bis(4-methylbenzoyloxy)succinic acid; (S)-Venlafaxine Di-p-Toluoyl-L-Tartrate; Venlafaxine (S)-enantiomer Di-p-Toluoyl-L-Tartrate Salt; (S)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Di-p-Toluoyl-L-Tartrate; Venlafaxine S-Enantiomer Tartrate Derivative; L-Tartaric acid, bis(4-methylbenzoate), salt with (S)-venlafaxine (2:1).
EINECS	Contact for details

Quality Control

Our S-Venlafaxine-Di-p-Toluoyl-L-Tartrate Salt (2:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be resealed immediately after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.