Description

Desvenlafaxine (o-Desmethyl Venlafaxine) Fumarate is a high-purity active pharmaceutical ingredient (API) and a major active metabolite of the antidepressant venlafaxine. This compound is critical for the development and production of next-generation serotonin-norepinephrine reuptake inhibitor (SNRI) medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions focused on central nervous system (CNS) therapeutics and generic drug formulation.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of antidepressant medications.
• Reference Standard: Used in analytical laboratories for quality control, method development, and pharmacokinetic studies.
• Research & Development: Critical for preclinical and clinical research into mood disorders, neuropathic pain, and other CNS conditions.
• Generic Drug Formulation: Serves as the key component for developing bioequivalent generic versions of SNRI drugs.
• Metabolite Studies: Employed in drug metabolism and pharmacodynamics (DMPK) research to understand venlafaxine's activity profile.

Basic Information

Product Name	Desvenlafaxine (o-Desmethyl Venlafaxine) Fumarate
CAS No.	93414-04-1
Molecular Formula	C18H27NO2 • C4H4O4
Molecular Weight	463.50 g/mol
Synonyms	O-Desmethylvenlafaxine Fumarate; Desvenlafaxine Succinate (common misnomer); Pristiq (Trade Name API); WY-45233; (1R,2R)-2-(Dimethylamino)-1-(4-hydroxy-3-methoxyphenyl)propyl cyclohexanol fumarate; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-2-methoxyphenol fumarate; Venlafaxine Metabolite ODV Fumarate
EINECS	Contact for details

Quality Control

Our Desvenlafaxine Fumarate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with high-purity pharmacopeial standards, including identification, assay, and control of specific impurities. A comprehensive Certificate of Analysis (COA) documenting purity, residual solvents, and heavy metals is provided with every shipment to guarantee traceability and regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.