Description

o-Desmethylvenlafaxine (CAS NO 93413-62-8) is a key pharmaceutical intermediate and the primary active metabolite of the antidepressant venlafaxine. This compound is critical for research and development in neuropharmacology and for the synthesis of related therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of serotonin-norepinephrine reuptake inhibitors (SNRIs) and associated analytical standards.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of venlafaxine and its derivatives.
• Active Pharmaceutical Ingredient (API) Research: Serves as a reference standard and starting material for developing novel SNRIs.
• Metabolite Standard: Essential for bioanalytical method development and pharmacokinetic studies in clinical and preclinical research.
• Biochemical Research: Used in studies investigating neurotransmitter reuptake mechanisms and receptor binding assays.
• Quality Control & Regulatory Compliance: Acts as a critical reference compound for impurity profiling and ensuring API quality according to ICH guidelines.

Basic Information

Product Name	o-Desmethylvenlafaxine
CAS No.	93413-62-8
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	O-Desmethylvenlafaxine; Desvenlafaxine; ODV; (R/S)-1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol; WY-45233; JNJ-7925476
EINECS	Contact for details

Quality Control

Our o-Desmethylvenlafaxine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for pharmaceutical R&D. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH Q3A/B guidelines for impurities and can supply material that meets in-house specifications aligned with industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.