Description

R-Venlafaxine is the single enantiomer of the antidepressant Venlafaxine, specifically targeting the (R)-configuration. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical compounds where stereochemical purity directly impacts therapeutic efficacy and safety. It is essential for pharmaceutical R&D laboratories and manufacturers specializing in the production of enantiomerically pure active pharmaceutical ingredients (APIs) for central nervous system (CNS) therapies.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of enantiomerically pure Venlafaxine and its derivatives.
• Active Pharmaceutical Ingredient (API) Research: Serves as a critical starting material or intermediate in the R&D of novel serotonin-norepinephrine reuptake inhibitors (SNRIs).
• Reference Standard: Used as an analytical standard in HPLC, LC-MS, and chiral chromatography for method development, validation, and quality control.
• Process Chemistry & Scale-up: Employed in process optimization and pilot-scale manufacturing of stereospecific antidepressant drugs.
• Academic & Contract Research: Utilized in university and CRO settings for pharmacological studies and the development of new CNS-targeting molecular entities.

Basic Information

Product Name	R-Venlafaxine
CAS No.	93413-46-8
Molecular Formula	C17H27NO2
Molecular Weight	277.40 g/mol
Synonyms	(R)-Venlafaxine; (R)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol; (R)-O-Desmethylvenlafaxine; UNII-7D7RX5A8MO; (2R)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; Venlafaxine R-isomer; (R)-(-)-Venlafaxine
EINECS	Contact for details

Quality Control

Our R-Venlafaxine CAS NO 93413-46-8 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.