Description

3,3,4,4,4-Pentafluoro-2-Hydroxy-2-(p-Tolyl)-Butyric Acid is a high-value fluorinated organic building block characterized by a unique combination of a pentafluoroalkyl chain and a chiral hydroxy acid moiety. This compound matters as a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where its fluorine atoms impart enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced, high-performance pesticides and herbicides where the fluorine content improves activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Modification: Incorporated as a monomer or additive to introduce fluorine into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in asymmetric synthesis and cross-coupling reactions to construct complex, fluorinated molecular architectures.
• Material Science Research: Employed in developing novel fluorinated surfactants, coatings, and electronic materials.

Basic Information

Product Name	3,3,4,4,4-Pentafluoro-2-Hydroxy-2-(p-Tolyl)-Butyric Acid
CAS No.	91935-84-1
Molecular Formula	C11H9F5O3
Molecular Weight	284.18 g/mol
Synonyms	2-Hydroxy-2-(4-methylphenyl)-3,3,4,4,4-pentafluorobutanoic acid; α-Hydroxy-α-(p-tolyl)-γ,γ,γ-trifluoropentafluorobutyric Acid; Pentafluoro-2-hydroxy-2-(p-tolyl)butyric Acid; 4-Methyl-α-(1-hydroxy-2,2,3,3,3-pentafluoropropyl)benzoic Acid; (RS)-3,3,4,4,4-Pentafluoro-2-hydroxy-2-(p-tolyl)butyric acid; 91935-84-1; Butyric acid, 3,3,4,4,4-pentafluoro-2-hydroxy-2-(4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 3,3,4,4,4-Pentafluoro-2-Hydroxy-2-(p-Tolyl)-Butyric Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, NMR, and MS for structural confirmation, to ensure compliance with precise customer specifications and industry standards. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.