Description

Camptothecin, [(G)3H] is a tritium-labeled derivative of the potent topoisomerase I inhibitor, camptothecin. This labeled compound is essential for advanced pharmacological and biochemical research, enabling precise tracking of drug metabolism, distribution, and receptor binding studies. It is a critical tool for researchers and developers in the fields of oncology drug discovery, pharmacokinetics, and molecular biology.

Application

• Tracer Studies in Drug Metabolism & Pharmacokinetics (DMPK): Used to quantitatively study the absorption, distribution, metabolism, and excretion (ADME) of camptothecin and its analogs.
• Mechanism of Action Research: Employed in binding assays to investigate the interaction between topoisomerase I inhibitors and their DNA-enzyme complex target.
• Autoradiography & Imaging: Serves as a radioligand for autoradiographic techniques to visualize drug localization in tissues and cells.
• Biochemical Assay Development: Acts as a standard or tracer in the development of high-throughput screening (HTS) assays for novel anticancer agents.
• Metabolic Pathway Analysis: Facilitates the identification and quantification of camptothecin metabolites in in vitro and in vivo systems.
• Quality Control for Radiolabeled Formulations: Used as a reference standard in the quality assurance of therapeutic radiopharmaceuticals.

Basic Information

Product Name	Camptothecin, [(G)3H]
CAS No.	91926-09-9
Molecular Formula	C20H153HN2O4
Molecular Weight	~ 349.3 g/mol (for unlabeled form)
Synonyms	(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (G)3H-labeled; (S)-Camptothecin, tritium labeled; [3H]-Camptothecin; CPT, [3H]-; NSC 94600, tritiated; Topotecan precursor, labeled; Tritiated Camptothecin
EINECS	Contact for details

Quality Control

Our Camptothecin, [(G)3H] is produced and handled under strict quality protocols to ensure radiochemical purity and specific activity are consistent and reliable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as radionuclidic purity, chemical purity, and solvent composition. We adhere to GMP-like guidelines for the handling of radioactive materials to ensure product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). Store in accordance with all local and national regulations for radioactive materials. Allow the product to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or solution
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-30 Ci/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol, Toluene, or custom (Specified on COA)
Concentration (if supplied as solution)	1.0 mCi/mL ± 10% (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.