Description

Dl-4-Hydroxyphenyl(Alanine-1-13C) is a stable isotope-labeled analog of the amino acid tyrosine, where a carbon-13 atom is incorporated at the 1-position of the alanine moiety. This compound is a critical tool for advanced research, enabling precise metabolic pathway tracing, protein dynamics studies, and quantitative analysis via mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and analytical laboratories focused on proteomics, metabolomics, and drug discovery.

Application

• Metabolic Pathway Tracing: As an internal standard for tracking tyrosine metabolism and phenylalanine/tyrosine-derived compound synthesis in biological systems.
• Quantitative Mass Spectrometry: Serving as a stable isotope-labeled internal standard for the accurate quantification of tyrosine and related metabolites in complex biological matrices (e.g., plasma, tissue, cell culture).
• Proteomics Research: Used in Stable Isotope Labeling by Amino acids in Cell culture (SILAC) and other techniques to study protein turnover, synthesis rates, and post-translational modifications.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for novel therapeutics that interact with amino acid pathways.
• NMR Spectroscopy: Facilitating structural and dynamic studies of proteins and peptides by providing a site-specific 13C label.
• Biochemical Research: Investigating enzyme mechanisms, particularly those of tyrosine hydroxylase, tyrosine aminotransferase, and other enzymes in catecholamine biosynthesis.

Basic Information

Product Name	Dl-4-Hydroxyphenyl(Alanine-1-13C)
CAS No.	91679-34-4
Molecular Formula	C9H11NO3 (with 13C at specified position)
Molecular Weight	~182.18 g/mol (13C adjusted)
Synonyms	DL-4-Hydroxyphenylalanine-1-13C; DL-Tyrosine-1-13C; (RS)-2-Amino-3-(4-hydroxyphenyl)propanoic acid-1-13C; 3-(4-Hydroxyphenyl)-DL-alanine-1-13C; DL-β-(4-Hydroxyphenyl)alanine-1-13C; HPA-1-13C; 13C Labeled DL-Tyrosine; Tyrosine (DL, 1-13C)
EINECS	Contact for details

Quality Control

Our Dl-4-Hydroxyphenyl(Alanine-1-13C) is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and specific analytical results. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C label position confirmed)
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C (at the 1-position)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.