Description

Napamezole is a selective and potent α-2 adrenoceptor antagonist with significant research and development interest. This compound is valued for its high pharmacological specificity, making it a crucial reference standard and active pharmaceutical ingredient (API) intermediate in neuroscience and cardiovascular research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers developing novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis of novel central nervous system (CNS) and cardiovascular drugs.
• Neuroscience Studies: Used in preclinical research to investigate the role of α-2 adrenergic receptors in depression, anxiety, and cognitive functions.
• Biochemical Assay Development: Serves as a selective ligand for validating and calibrating assays targeting α-2 adrenoceptor activity.
• Metabolism and Pharmacokinetics (DMPK): Employed in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profiles of related compounds.
• Fine Chemical Synthesis: A building block for the custom synthesis of more complex, targeted molecules for clinical evaluation.
• Academic Research: Utilized in university and institutional labs for fundamental pharmacological studies and publications.

Basic Information

Product Name	Napamezole
CAS No.	91524-14-0
Molecular Formula	C15H18N2O
Molecular Weight	242.32 g/mol
Synonyms	2-(1-Naphthylmethyl)-2-imidazoline; 2-[(1-Naphthalenyl)methyl]-4,5-dihydro-1H-imidazole; 2-(1-Naphthylmethyl)imidazoline; 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole; Napamezole hydrochloride (salt form); α-2 adrenergic antagonist; EINECS Contact for details

Quality Control

Our Napamezole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and impurity profiling to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.