Description

2-Azetidinone, 4-Ethynyl-3-(1-Hydroxyethyl)-, [3Alpha(R*),4Alpha]- (9Ci) is a high-value, stereochemically defined β-lactam building block. This compound matters as a critical chiral synthon for the research and development of novel pharmaceutical agents, particularly in the synthesis of complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating new drug candidates and advanced intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel β-lactam antibiotics and other pharmacologically active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and for constructing complex molecular architectures in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: The ethynyl and hydroxyl functional groups make it suitable for conjugation and labeling applications in probe development.
• Asymmetric Synthesis: Utilized as a chiral template or auxiliary in stereoselective synthesis to induce specific stereochemistry in final products.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of high-value, complex organic molecules beyond pharmaceuticals.

Basic Information

Product Name	2-Azetidinone, 4-Ethynyl-3-(1-Hydroxyethyl)-, [3Alpha(R*),4Alpha]- (9Ci)
CAS No.	90696-34-7
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	4-Ethynyl-3-(1-hydroxyethyl)azetidin-2-one; (3R,4R)-4-Ethynyl-3-(1-hydroxyethyl)azetidin-2-one; [3α(R*),4α]-4-Ethynyl-3-(1-hydroxyethyl)-2-azetidinone; β-Lactam, 4-ethynyl-3-(1-hydroxyethyl)-, (3R,4R)-; Azetidin-2-one, 4-ethynyl-3-(1-hydroxyethyl)-, (3R,4R)-; Chiral β-lactam intermediate; 90696-34-7
EINECS	Contact for details

Quality Control

Our 2-Azetidinone, 4-Ethynyl-3-(1-Hydroxyethyl)-, [3Alpha(R*),4Alpha]- (9Ci) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. All products undergo rigorous analytical testing, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.