Description

(R)-Methyl 2-Hydroxy-3-Methylbutanoate is a chiral ester of significant interest in fine chemical synthesis. This compound serves as a valuable chiral building block and intermediate for the production of pharmaceuticals, agrochemicals, and high-value flavor and fragrance ingredients. It is particularly sought after by research institutions and industrial manufacturers in the pharmaceutical, flavor & fragrance, and advanced material sectors for its utility in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in antiviral and cardiovascular drug research.
• Flavor & Fragrance Ingredient: Used as a precursor for creating optically active esters and lactones that contribute to complex, natural flavor profiles.
• Agrochemical Synthesis: Intermediate in the production of chiral pesticides and herbicides, where stereochemistry is crucial for biological activity.
• Asymmetric Catalysis: Employed as a chiral auxiliary or ligand precursor in catalytic processes to induce enantioselectivity.
• Organic Synthesis Research: A versatile starting material in academic and industrial R&D for exploring new synthetic methodologies.
• Specialty Polymer Modification: Can be used to introduce chiral centers into polymer backbones for advanced material properties.

Basic Information

Product Name	(R)-Methyl 2-Hydroxy-3-Methylbutanoate
CAS No.	90244-32-9
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(R)-Methyl 2-Hydroxy-3-methylbutyrate; (R)-Methyl 2-Hydroxyisovalerate; Methyl (R)-(-)-2-Hydroxy-3-methylbutyrate; (R)-2-Hydroxy-3-methylbutyric acid methyl ester; (R)-HMB Methyl Ester; (2R)-2-Hydroxy-3-methylbutanoic acid methyl ester; L-Valine lactone derivative
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-Hydroxy-3-Methylbutanoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC or GC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and organic solvents. Recommended storage temperature is 2-8°C for long-term stability to maintain chiral integrity and prevent ester hydrolysis or racemization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.