Description

Acetaminophen-Ring-Ul- 14 C is a carbon-14 labeled isotopologue of the widely used analgesic and antipyretic compound, acetaminophen (paracetamol). This product is specifically designed for advanced pharmaceutical research, enabling precise metabolic and pharmacokinetic studies through radiotracer techniques. It is an essential tool for scientists and R&D departments in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, stable-isotope labeled materials for drug development and regulatory submission support.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of acetaminophen in preclinical and clinical research.
• Mass Spectrometry Internal Standards: Serving as a critical internal standard for the accurate quantification of acetaminophen and its metabolites using LC-MS/MS and GC-MS methods.
• Mechanistic Toxicology Research: Investigating the bioactivation pathways and the formation of reactive metabolites linked to acetaminophen-induced hepatotoxicity.
• Environmental Fate Studies: Tracking the environmental persistence and breakdown products of pharmaceutical compounds in ecological systems.
• Synthesis of Labeled Metabolites: Used as a precursor for the chemical or enzymatic synthesis of carbon-14 labeled metabolites for further biological testing.
• Regulatory Submission Support: Providing essential data for regulatory filings with agencies like the FDA and EMA that require radiolabeled studies for new drug applications.

Basic Information

Product Name	Acetaminophen-Ring-Ul- 14 C
CAS No.	90135-67-4
Molecular Formula	C8H914CNO2
Molecular Weight	~153.14 g/mol (exact mass depends on 14C enrichment)
Synonyms	Paracetamol (Ring-Ul-14C); 4'-Hydroxyacetanilide-14C; N-(4-Hydroxyphenyl)acetamide-14C; APAP-14C; [Ring-U-14C]Acetaminophen; Carbon-14 Labeled Acetaminophen; [14C]-Paracetamol; Uniformly Labeled 14C-Acetaminophen
EINECS	Contact for details

Quality Control

Every batch of Acetaminophen-Ring-Ul- 14 C is manufactured and analyzed under strict quality systems. We ensure compliance with high-purity standards typical for radiolabeled reference materials. Critical parameters including radiochemical purity, chemical purity, and specific activity are rigorously verified. A comprehensive Certificate of Analysis (COA) detailing analytical methods (HPLC, TLC, MS) and results is provided with each shipment to guarantee traceability and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solution forms)	Ethanol or other suitable solvent (specified per batch)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.