Description

Carboxyhemoglobin is a stable, colored complex formed by the binding of carbon monoxide to the heme iron of hemoglobin. This compound is of critical importance in biomedical research and clinical diagnostics for studying carbon monoxide poisoning, oxygen transport physiology, and hemoglobinopathies. It serves as an essential reference material and calibrator for analytical laboratories, clinical chemistry departments, and research institutions focused on respiratory and toxicological studies.

Application

• Clinical Diagnostics & Calibration: Primary standard and calibrator for blood gas analyzers and CO-oximeters to accurately measure carboxyhemoglobin levels in patient blood samples.
• Toxicology Research: Critical reagent for in-vitro studies modeling carbon monoxide poisoning, investigating its biochemical mechanisms, and evaluating potential antidotes.
• Physiological Studies: Used in research on hemoglobin's oxygen-binding affinity, allosteric effects, and the competitive binding dynamics between CO, O2, and other ligands.
• Quality Control (QC) Material: Serves as a verified control material for laboratory proficiency testing and internal QC programs in hospital and reference labs.
• Biochemical Reagent: Employed in enzymatic assays and spectroscopic studies that require a defined, stable form of hemoglobin with altered ligand-binding properties.
• Forensic Science: Used as a reference standard in forensic analyses to confirm and quantify CO exposure in post-mortem investigations.

Basic Information

Product Name	Carboxyhemoglobin
CAS No.	9061-29-4
Molecular Formula	C2952H4664N812O840S8Fe4 (for human hemoglobin tetramer)
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Carbon Monoxide Hemoglobin; CO-Hemoglobin; HbCO; Carboxyhaemoglobin; Hemoglobin, carbonmonoxy; Carbonylhemoglobin; Carbhemoglobin; COHb
EINECS	Contact for details

Quality Control

Our Carboxyhemoglobin is produced and handled under controlled conditions to ensure batch-to-batch consistency and reliability for critical applications. Each lot undergoes rigorous analytical testing, including spectrophotometric purity assessment, methemoglobin content determination, and verification of CO saturation percentage. A comprehensive Certificate of Analysis (COA) detailing identity, purity, concentration, and physicochemical parameters is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. For short-term use, storage at 2-8°C is acceptable. This material is hygroscopic (moisture-sensitive); ensure containers are sealed properly after each use to prevent absorption of atmospheric moisture. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Dark red, homogeneous solution or lyophilized powder
Identification (UV-Vis)	Spectrum conforms to reference
Purity (Spectrophotometric)	≥ 95% (as Carboxyhemoglobin)
CO Saturation	≥ 98%
Methemoglobin Content	≤ 2.0%
Protein Concentration	As stated on COA (typically 5-10 g/dL)
Solvent / Buffer	Phosphate Buffered Saline or as specified
pH	7.2 - 7.6
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.