Description

Isodesmosine Standard CAS NO 991-01-5 is a high-purity biochemical reference material, specifically a cross-linking amino acid derived from elastin. This compound is critical for the accurate quantification and study of elastin metabolism and degradation. It serves as an essential analytical standard for researchers and quality control laboratories in the life sciences, pharmaceutical development, and diagnostic sectors requiring precise biomarker analysis.

Application

• Biomarker Research & Assay Development: Primary standard for developing and validating quantitative assays (e.g., LC-MS/MS, ELISA) to measure isodesmosine levels in biological fluids as a biomarker for elastin turnover.
• Pulmonary & Cardiovascular Disease Studies: Used in research investigating conditions like chronic obstructive pulmonary disease (COPD), atherosclerosis, and Marfan syndrome, where elastin degradation is a key pathological feature.
• Pharmaceutical R&D: Essential reference compound in drug discovery programs targeting elastases or aiming to modulate elastin synthesis and repair.
• Diagnostic Kit Manufacturing: Serves as a critical calibrant and control in the production of in-vitro diagnostic (IVD) kits for connective tissue disorders.
• Nutritional & Anti-Aging Research: Applied in studies examining the effects of diet, supplements, and treatments on skin and tissue elasticity.
• Forensic & Tissue Analysis: Used as a standard in forensic science for age estimation and tissue analysis based on stable elastin crosslinks.
• Quality Control & Method Validation: Provides an authoritative reference for analytical method validation, ensuring accuracy and reproducibility in laboratory testing.

Basic Information

Product Name	Isodesmosine Standard
CAS No.	991-01-5
Molecular Formula	C24H36N4O8
Molecular Weight	508.57 g/mol
Synonyms	Isodesmosine; (2S)-2-Amino-5-[(4S)-4-Amino-4-carboxybutyl]-1-(3S)-5-amino-5-carboxypentyl)-3,4-dihydro-1H-pyridin-4-ium-3,5-dicarboxylate; L-Isodesmosine; Elastin Crosslink; Pyridinium Crosslink Amino Acid; 2,2'-Bis(3,5-dicarboxy-4-aminophenyl)propane (common misnomer); 1,3-Bis(4-amino-3,5-dicarboxyphenyl)propane (common misnomer)
EINECS	Contact for details

Quality Control

Our Isodesmosine Standard is manufactured under strict quality management systems. Each batch undergoes rigorous identity confirmation, purity analysis, and stability testing to ensure it meets the exacting requirements of analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods (e.g., HPLC, MS) is provided with every shipment to guarantee traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (by weight)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.