Description

L-Valine-Ul-14C is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-Valine, identified by CAS No. 921-10-8. This radiolabeled compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering unparalleled precision in tracking the fate of valine in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in the fields of biochemistry, drug metabolism, and nutritional science.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of valine-containing compounds or related drugs.
• Biochemical Pathway Analysis: Essential for tracing the metabolic pathways of valine in vivo, including its role in protein synthesis, gluconeogenesis, and the citric acid cycle.
• Nutritional and Metabolic Research: Employed to study valine utilization, turnover rates, and its impact on muscle metabolism and energy balance in clinical and preclinical models.
• Proteomics and Protein Turnover Studies: Facilitates the measurement of protein synthesis and degradation rates by incorporating the labeled amino acid into newly synthesized proteins.
• Radiochemical Synthesis: Serves as a labeled building block for the synthesis of more complex carbon-14 labeled molecules for research purposes.
• Environmental Fate Studies: Applied in specialized research to track the biodegradation and environmental fate of valine or related organic compounds.

Basic Information

Product Name	L-Valine-Ul-14C
CAS No.	921-10-8
Molecular Formula	C5H1114CNO2 *
Molecular Weight	Contact for details
Synonyms	(2S)-2-Amino-3-methylbutanoic acid (U-14C); L-2-Amino-3-methylbutyric acid (U-14C); (S)-Valine (U-14C); Uniformly Labeled Carbon-14 L-Valine; [U-14C]-L-Valine; Valine (U-14C); L-Valine (carbon-14 labeled)
EINECS	Contact for details

* Formula indicates uniform carbon-14 labeling across all carbon atoms.

Quality Control

Every batch of L-Valine-Ul-14C is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as radiochemical purity (by HPLC), specific activity, chemical purity, and solvent content. Our quality commitment aligns with the rigorous demands of preclinical and clinical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. Store in accordance with all local and national regulations for radioactive materials. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere after use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 98%
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Solvent (if present)	Specified on COA
Radioactivity Concentration	As per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.