Description

Pilocarpine is a naturally occurring alkaloid and a potent parasympathomimetic agent, primarily known for its muscarinic receptor agonist activity. This high-purity compound is essential for pharmaceutical research and manufacturing, where consistent quality and reliable supply are paramount. It serves as a critical active pharmaceutical ingredient (API) for the production of ophthalmic solutions used in the treatment of glaucoma and other conditions, making it indispensable for pharmaceutical companies, contract research organizations (CROs), and advanced research institutions globally.

Application

• Ophthalmic Pharmaceutical Manufacturing: Primary API in eye drops for the treatment of glaucoma and ocular hypertension.
• Research & Development: Key reference standard and tool compound in pharmacological studies of the cholinergic system and muscarinic receptors.
• Diagnostic Use: Employed in sweat tests (e.g., pilocarpine iontophoresis) for the diagnosis of cystic fibrosis.
• Dry Mouth Treatment (Xerostomia): Used in formulations to stimulate salivary secretion in patients with Sjögren's syndrome or radiation-induced dryness.
• Chemical Synthesis: Serves as a chiral building block or precursor in the synthesis of more complex pharmaceutical molecules.
• Veterinary Medicine: Applied in ophthalmic treatments for animals.

Basic Information

Product Name	Pilocarpine
CAS No.	92-13-7
Molecular Formula	C11H16N2O2
Molecular Weight	208.26 g/mol
Synonyms	Pilocarpine; (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one; Pilocarpine alkaloid; Pilocarpus alkaloid; Pilocarpidine; Isopilocarpine (mixture); Ocusert Pilo; Pilokar; Pilopt; Contact for additional synonyms.
EINECS	202-127-1

Quality Control

Our Pilocarpine is manufactured under strict quality management systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and GC. We can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder or colorless crystals
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+80° to +90° (c=1 in H2O)
Water (Karl Fischer)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.