Description

4-Pyrimidinamine-n-15N is a stable isotope-labeled analog of 4-aminopyrimidine, where the nitrogen atom in the amine group is enriched with the 15N isotope. This compound is essential for advanced research and development, providing a critical internal standard for quantitative mass spectrometry and a tracer for elucidating metabolic pathways and reaction mechanisms. It is primarily utilized by scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require high-purity, isotopically labeled building blocks for drug discovery, environmental analysis, and metabolic studies.

Application

• As an internal standard for the accurate quantification of 4-aminopyrimidine and related compounds in complex biological matrices using LC-MS or GC-MS.
• A metabolic tracer in pharmacokinetic and drug metabolism studies to track the fate of pyrimidine-based drug candidates.
• A key labeled synthetic intermediate for the preparation of more complex 15N-labeled heterocyclic compounds in medicinal chemistry.
• Use in NMR spectroscopy as a probe to study molecular structure, dynamics, and interactions due to the distinct nuclear magnetic resonance of the 15N nucleus.
• Fundamental research in chemical reaction mechanisms involving nitrogen transfer or rearrangement.
• Development of diagnostic assays and analytical reference materials for clinical and environmental testing laboratories.

Basic Information

Product Name	4-Pyrimidinamine-n-15N
CAS No.	898225-65-5
Molecular Formula	C4H515N3
Molecular Weight	97.10 g/mol (for 15N labeled form)
Synonyms	4-Aminopyrimidine-15N; 4-Pyrimidinamine-15N; 15N-4-Aminopyrimidine; Pyrimidin-4-amine-15N; 1,3-Diazin-4-amine-15N; 4-15N-Aminopyrimidine; 4-Pyridinamine-15N (incorrect but common search variant); Isotope Labeled 4-AP
EINECS	Contact for details

Quality Control

Every batch of 4-Pyrimidinamine-n-15N is produced and analyzed under strict quality management protocols. We guarantee high chemical purity and isotopic enrichment, with specifications typically including assay by HPLC, isotopic purity by MS or NMR, and identification by IR spectroscopy. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing all analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (15N)	≥98 atom %
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.